Physical activity programmes for community dwelling people with mild to moderate dementia (DAPA - Dementia And Physical Activity)

Conditions

Dementia Mental and Behavioural Disorders Dementia

Sarah E Lamb, Bart Sheehan, Nicky Atherton, Vivien Nichols, Helen Collins et al. (11 authors)

BMJ2018-05-16401 citations

Aerobic and strength training exercise programme for cognitive impairment in people with mild to moderate dementia: the DAPA RCT.

Lamb SE, Mistry D, Alleyne S, Atherton N, Brown D, Copsey B, Dosanjh S, Finnegan S, Fordham B, Griffiths F, Hennings S, Khan I, Khan K, Lall R, Lyle S, Nichols V, Petrou S, Zeh P, Sheehan B.

2018-05-0141 citations

10.3310/hta22280

Dementia and Physical Activity (DAPA) - an exercise intervention to improve cognition in people with mild to moderate dementia: study protocol for a randomized controlled trial

Nicky Atherton, Christopher Bridle, Deborah J. Brown, Helen Collins, Sukhdeep Dosanjh et al. (20 authors)

Trials2016-03-2426 citations

10.1186/s13063-016-1288-2

Interventions

Current interventions as of 06/01/2015: Best practice usual care: All participants will receive care as usual from the clinical service they attend. All of the services participating i

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Probable dementia according to Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) criteria: 1.1. Memory impairment with cognitive disturbance in a least one of the following domains - aphasia (language), apraxia (motor activities), agnosia (object recognition) or executive functioning (planning, sequencing, abstracting) 1.2. Functional decline: increasing impairment in functional ability (social, occupational, personal/self-care) related to cognitive deficits 2. Probable dementia of mild to moderate severity (MMSE >10) 3. Are able to participate in a structured exercise program: 3.1. Are able to sit on a chair and walk 10 feet without human assistance 3.2. No serious unstable illness (e.g. unstable angina) 4. Live in the community, either alone or with a relative, friend, or carer, or in sheltered accomodation

Exclusion criteria

Exclusion criteria: 1. People with severe dementia (MMSE <10) 2. People living in residential nursing homes 3. People with acute, unstable or terminal illness which would make participation in the exercise group impractical

Design outcomes

Primary

Measure	Time frame
Current primary outcome measures as of 06/01/2015: The primary outcome measure will be cognition 1. Cognitive function will be measured using the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) at 0, 6 and 12 months Previous primary outcome measures: The primary outcome measure will be cognition at 0, 6 and 12 months 1. Cognitive function will be measured using the Mini Mental State Examination (MMSE) 2. Function will be measured using the Bristol Activity of Daily Living scale (BADL)	—

Measure

Time frame

Current primary outcome measures as of 06/01/2015: The primary outcome measure will be cognition 1. Cognitive function will be measured using the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) at 0, 6 and 12 months Previous primary outcome measures: The primary outcome measure will be cognition at 0, 6 and 12 months 1. Cognitive function will be measured using the Mini Mental State Examination (MMSE) 2. Function will be measured using the Bristol Activity of Daily Living scale (BADL)

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Secondary

Measure	Time frame
Current secondary outcome measures as of 06/01/2015: 1. Function: measured using the Bristol Activity of Daily Living scale (BADL) at 0, 6 and 12 months 2. Health-related quality of life: measured using (EuroQol EQ-5D) at 0, 6 and 12 months 3. Dementia quality of life; measured using (QoL-AD) at 0, 6 and 12 months 4. Behavioural symptoms: measured using the Neuropsychiatric Index (NPI) at 0, 6 and 12 months 5. Carer burden: measured using Zarit Burden Interview (ZBI) at 0, 6 and 12 months Previous secondary outcome measures: 1. Health-related quality of like (EuroQol EQ-5D) at 0, 6 and 12 months 2. Dementia quality of life (Qol-AD) at 0, 6 and 12 months 3. Behavioural symptoms (NPI) at 0, 6 and 12 months 4. Mood (Cornell Scale for Depression in Dementia [CSDD]) at 0, 6 and 12 months 5, Carer burden (Zarit Burden Interview [ZBI]) 0, 6 and 12 months	—

Measure

Time frame

Current secondary outcome measures as of 06/01/2015: 1. Function: measured using the Bristol Activity of Daily Living scale (BADL) at 0, 6 and 12 months 2. Health-related quality of life: measured using (EuroQol EQ-5D) at 0, 6 and 12 months 3. Dementia quality of life; measured using (QoL-AD) at 0, 6 and 12 months 4. Behavioural symptoms: measured using the Neuropsychiatric Index (NPI) at 0, 6 and 12 months 5. Carer burden: measured using Zarit Burden Interview (ZBI) at 0, 6 and 12 months Previous secondary outcome measures: 1. Health-related quality of like (EuroQol EQ-5D) at 0, 6 and 12 months 2. Dementia quality of life (Qol-AD) at 0, 6 and 12 months 3. Behavioural symptoms (NPI) at 0, 6 and 12 months 4. Mood (Cornell Scale for Depression in Dementia [CSDD]) at 0, 6 and 12 months 5, Carer burden (Zarit Burden Interview [ZBI]) 0, 6 and 12 months

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Countries

United Kingdom

Outcome results

None listed