Urinary tract infection Urological and Genital Diseases Urinary tract infection
Conditions
Interventions
Ten healthy women will be enrolled and randomized for the intervention. Subjects will be randomized, based on a computer randomization plan. Two different food supplements, based on standardized cran
Sponsors
Indena Spa
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women 2. Age 18-40 years 3. BMI 18-25 kg/m2 4. Healthy
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Allergy to cranberry 3. Gastrointestinal disorder 4. Liver and renal disease 5. Antibiotic treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection at time 1, 2, 4, 6, 10,12, 14, 24, 48 hours (from the intake of the last capsule) of cranberry bioactive constituents in urine (type A proanthocyanidin) and metabolites including hydroxybenzoic acids and valerolactones evaluated by high-resolution mass spectrometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Detection of other potential cranberry polyphenol metabolites in urines evaluated by high-resolution mass spectrometry 2. Ex-vivo inhibition of Candida albicans adhesion and biofilm formation by using the urine collected from the subjects at different time points | — |
Countries
Italy
Outcome results
None listed