Ultrasound contrast agents to facilitate sonothrombolysis in patients with acute myocardial infarction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN32486185

Enrollment

Registered

2005-12-20

Start date

2005-10-01

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute myocardial infarction Circulatory System Acute myocardial infarction

Interventions

After having received 150 - 325 mg aspirin and a loading dose of 300 mg clopidogrel, patients will be randomised to: 1. Ultrasound application with infusion of an ultrasound contrast a

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18 to 80 years 2. Diagnosed with acute myocardial infarction according to the criteria of the American College of Cardiology 3. Informed consent

Exclusion criteria

Exclusion criteria: 1. Previous myocardial infarction 2. Clinical instability 3. Pregnancy/breast feeding 4. Known pulmonary hypertension 5. Known allergy to Optison 6. Any reason judged by the investigators to hamper inclusion

Design outcomes

Primary

Measure	Time frame
Comparison of the UCA-group and the control group with respect to: 1. Patency of the culprit coronary artery 2. Thrombolysis In Myocardial Infarction (TIMI)-flow 3. Corrected TIMI frame count 4. Myocardial blush grade	—

Secondary

Measure	Time frame
1. ST-segment resolution 2. Release of cardiac enzymes 3. Echocardiographic wall motion score index 4. Safety	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026