Osteoarthrosis Musculoskeletal Diseases Osteoarthritis
Conditions
Interventions
Routinely collected healthcare data analysis:
Analysis of routinely collected observational healthcare datasets (Clinical Practice Research Datalink, Hospital Episode Statistics and NHS Digital Patie
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Qualitative interviews: 1. Patients who have received intra-articular injections of corticosteroid for osteoarthritis 2. Received recurrent injections 3. Patients with osteoarthritis who have not received injections 4. Clinicians who have experience of prescribing and administering intra-articular injections of corticosteroid and those who have not administered injections. Delphi survey: 1. Patients, healthcare professionals involved in the treatment of patients with joint disease, academics and commissioners
Exclusion criteria
Exclusion criteria: Does not meet inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Routinely collected healthcare data analysis: 1. Current practice of the joint site (knee, hip, hand, shoulder, ankle/foot, wrist, and elbow) for intra-articular corticosteroid injections measured from Clinical Practice Research Datalink (CPRD) data collected for the period 01/01/2005 to 20/10/2017 2. Incidence and prevalence of use of intra-articular corticosteroid injections measured from CPRD data collected for the period 01/01/2005 to 20/10/2017 3. Secular trends of use of injections over the overall population calculated from CPRD data collected for the period 01/01/2005 to 20/10/2017 4. Number of repeat injections over time measured from patient-level CPRD data collected for the period 01/01/2005 to 20/10/2017 5. Cumulative use (number of daily defined doses of steroid/s injected in total), and medication possession ratio (number of daily defined doses of steroid injected over the number of days from first to last injection) measured from patient-level CPRD data collected for the period 01/01/2005 to 20/10/2017 Qualitative interviews: Views and experiences of receiving and administering intra-articular steroid injections for painful osteoarthritis assessed using healthcare behaviour theory informed analysis of the transcripts of semi-structured in-depth interviews with patients and primary care clinicians at a single interview Delphi survey: Future primary research priorities and associated feasibility assessed using a Delphi survey of patients, healthcare professionals, researchers, and commissioners over 3 rounds | — |
Secondary
| Measure | Time frame |
|---|---|
| Routinely collected healthcare data analysis: 1. Safety: 1.1. Use of post-operative (joint replacement surgery) analgesia (up to 1-year) including paracetamol (acetaminophen), topical & parenteral NSAIDs, opioid analgesia and/or use of gabapentinoids and anti-epileptic drugs measured from CPRD data collected for the period 01/01/2005 to 20/10/2017: 1.1.1. Number of medication prescriptions 1.1.2. Daily defined doses (DDD) of different types of analgesia (NSAID, opioids) received following the Index Prescription 1.2. Post-intra-articular injection and post-operative (joint replacement surgery) bleeding (up to 6-months) measured from CPRD data collected for the period 01/01/2005 to 20/10/2017 1.3. Post-intra-articular injection and post-operative (joint replacement surgery) infection (up to 6-months) measured from CPRD data collected for the period 01/01/2005 to 20/10/2017 1.4. Post-intra-articular injection and post-operative (joint replacement surgery) diabetes decompensation (up to 6-months) measured from Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES) data collected for the period 01/01/2005 to 20/10/2017 1.5. Post-intra-articular injection and post-operative (joint replacement surgery) cardiovascular events (up to 6-months) measured from CPRD and HES data collected for the period 01/01/2005 to 20/10/2017 1.6. Mortality (up to 6-months) measured from CPRD and HES data collected for the period 01/01/2005 to 20/10/2017 2. Use of post-intra-articular injection and post-operative (joint replacement surgery) steroid injections (up to 1-year) measured from CPRD data collected for the period 01/01/2005 to 20/10/2017 3. Use of post-intra-articular injection and post-operative (joint replacement surgery) oral corticosteroids (up to 1-year) measured from CPRD data collected for the period 01/01/2005 to 20/10/2017 4. Time to intermediate surgical interventions post-intra-articular injection including joint injections (up to 10-years), hip a | — |
Countries
England, United Kingdom
Outcome results
None listed