Type 2 diabetes mellitus Nutritional, Metabolic, Endocrine Diabetes
Conditions
Interventions
Aerobic and resistance exercise training versus none.
Sponsors
Ottawa Hospital Research Institute (OHRI) (Canada) - formerly Ottawa Health Research Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Type 2 diabetes mellitus as defined by the 1998 CDA guidelines 2. Male or female, treated with diet and/or oral agents (no insulin), aged 40 - 70 years, HbA1c 0.066 - 0.099
Exclusion criteria
Exclusion criteria: 1. Participation during the previous 6 months in a regular program of exercise or aerobic sports greater than or equal to 2 times/week for at least 20 minutes per session, or in any resistance training during the previous 6 months 2. Insulin therapy, or uncontrolled hyperglycaemia (HbA1c greater than 0.099). Insulin therapy is an exclusion criterion because it would render Homeostasis Model Assessment (HOMA) insulin sensitivity calculation invalid. 3. Changes in medications for diabetes in the 2 months prior to enrolment, or for blood pressure (BP) or lipids in the 1 month prior to enrolment 4. Significant weight change (increase or decrease of greater than or equal to 5% of body weight during the 2 months before enrolment) 5. Significant renal disease: serum creatinine greater than or equal to 200 mEq/1 or proteinuria greater than 1 g/24 hours 6. Uncontrolled hypertension: blood pressure (BP) greater than 160 mmHg systolic or greater than 95 mmHg diastolic BP in a sitting position 7. Restrictions in physical activity due to disease: intermittent claudication, severe peripheral neuropathy or active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis 8. Significant cognitive deficit resulting in inability to understand or comply with instructions 9. Other illness judged by the patient or study physician to make participation in this study inadvisable 10. Pregnancy at the start of the study, or intention to become pregnant in the next two years 11. Inability to communicate in English or French 12. Unwillingness to sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in haemoglobin A1c (HbA1c) between baseline and end of the 6-month supervised exercise period. HbA1c is a reflection of the mean blood glucose over the previous 2 - 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Change in health related quality of life 2. Nontraditional cardiovascular risk factors: Apo-B, Apo-A1, high-sensitivity C-reactive protein, LDL particle diameter, estimated insulin resistance 3. Blood pressure 4. Lipid concentrations 5. Body composition (weight, BMI, waist circumference, total body fat, visceral and subcutaneous abdominal fat, mid-thigh muscle cross-sectional area), lipids (Apo-B, Apo-A1, Apo-B/A1 ratio, LDL particle diameter, high-sensitivity C-reactive protein) 6. Resting metabolic rate | — |
Countries
Canada
Outcome results
None listed