Community-wide and School-based Mass Drug Administration (MDA), using praziquantel, given once each year compared to Community-wide and School-based Mass Drug Administration (MDA) given twice each year, six months a part, in gaining and sustaining control of Schistosoma haematobium

Conditions

Schistosomiasis Infections and Infestations Schistosomiasis

Shen Y, King CH, Binder S, Zhang F, Whalen CC, Evan Secor W, Montgomery SP, Mwinzi PNM, Olsen A, Magnussen P, Kinung'hi S, Phillips AE, Nalá R, Ferro J, Aurelio HO, Fleming F, Garba A, Hamidou A, Fenwick A, Campbell CH, Colley DG.

2017-09-2915 citations

10.1186/s12879-017-2738-5

Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries.

Ezeamama AE, He CL, Shen Y, Yin XP, Binder SC, Campbell CH, Rathbun S, Whalen CC, N'Goran EK, Utzinger J, Olsen A, Magnussen P, Kinung'hi S, Fenwick A, Phillips A, Ferro J, Karanja DM, Mwinzi PN, Montgomery S, Secor WE, Hamidou A, Garba A, King CH, Colley DG.

2016-05-2655 citations

10.1186/s12879-016-1575-2

Interventions

In a first step, in-depth parasitological surveys are carried out to identify 225 schools where the prevalence of S. haematobium (i.e. number of infections) amongst schoolchildren is greater than 10%.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Schoolchildren, either male or female, aged 9-12 years, attending the selected schools (in each study year) 2. First-year students, either male or female, attending the selected schools (in years 1 and 5) 3. Written informed consent signed by parents or legal guardians of the schoolchildren 4. Oral assent from schoolchildren 5. At least one urine sample provided from 9- to 12- years- old children each study year 6. At least one urine sample provided from first-year students and adults in years 1 and 5

Exclusion criteria

Exclusion criteria: 1. Children not aged 9-12 years (in years 2, 3 and 4) 2. Adults in Years 2, 3 and 4 2. Children under 9 in Years 2, 3, 4 3. No written informed consent by parents or legal guardians of schoolchildren 4. No oral assent given by schoolchildren 5. No urine sample provided (for 9- to 12-year-old children in each study year; for first-year students and adults in years 1 and 5)

Design outcomes

Primary

Measure	Time frame
MDA strategy that is able to reduce S. haematobium infection measured by change in prevalence and intensity of Schistosoma haematobium infection in 9- to 12-year-old children is measured at baseline, 1, 2, 3 and 4 years by filtering the urine and preparing slide for microscopic exam. In addition, the urine is observed to see if hematuria visible.	—

Secondary

Measure	Time frame
1. Prevalence and intensity of S. haematobium infections in 9- to-12- year-old schoolchildren is measured at baseline, 1, 2, 3 and 4 years using urinalysis 2. Prevalence and intensity of S. haematobium infections in first-year schoolchildren is measured at baseline, 1, 2, 3 and 4 years using urinalysis 3. Identification of S. haematobium risk factors is measured by collecting village inventory data about water, sanitation, hygiene and water body contact at baseline, 1, 2, 3 and 4 years 5. Mapping and prediction of the distribution S. haematobium in Niger is measured by collecting and using GIS coordinates of schools, water bodies and water and sanitation infrastructure at baseline, 1, 2, 3 and 4 years	—

Measure

Time frame

1. Prevalence and intensity of S. haematobium infections in 9- to-12- year-old schoolchildren is measured at baseline, 1, 2, 3 and 4 years using urinalysis 2. Prevalence and intensity of S. haematobium infections in first-year schoolchildren is measured at baseline, 1, 2, 3 and 4 years using urinalysis 3. Identification of S. haematobium risk factors is measured by collecting village inventory data about water, sanitation, hygiene and water body contact at baseline, 1, 2, 3 and 4 years 5. Mapping and prediction of the distribution S. haematobium in Niger is measured by collecting and using GIS coordinates of schools, water bodies and water and sanitation infrastructure at baseline, 1, 2, 3 and 4 years

—

Countries

Niger

Contacts

Public ContactAmadou Garba

Outcome results

None listed