Combination therapy versus monotherapy: a randomised study on the evolution of inflammatory parameters after ventilator associated pneumonia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN31976779

Enrollment

150

Registered

2006-01-11

Start date

2002-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator associated pneumonia Respiratory Pneumonia

Interventions

Comparison between treatment with cefepime alone and cefepime associated with amikacin or levofloxacin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients with ventilator associated pneumonia

Exclusion criteria

Exclusion criteria: 1. Patients treated for other infection 2. Immunocompromised patients 3. Patients with life expectancy less than 72 hours

Design outcomes

Primary

Measure	Time frame
Time course evolution of C-reactive protein (CRP) levels, temperature and leucocytosis	—

Secondary

Measure	Time frame
1. Length of ventilatory support 2. Evolution of PaO2/FiO2 3. Mortality	—

Countries

Belgium

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026