Can an antibacterial coating on surfaces in an intensive care unit (ICU) prevent methicillin-resistant Staphylococcus aureus (MRSA) acquisition in patients?

Environmental disinfection with a photocatalyst antimicrobial coating as an adjunctive measure to control transmission of methicillin-resistant Staphylococcus aureus (MRSA) in patients in intensive care units (ICU): a prospective cohort study in a high-incidence setting

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN31972004

Enrollment

621

Registered

2018-11-19

Start date

2016-09-01

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Methicillin-resistant Staphylococcus aureus (MRSA) infection Infections and Infestations

Interventions

A titanium dioxide-based photocatalyst was coated on high touch surfaces and walls. 5 months of pre-intervention data were compared with 5 months of post-intervention data. The incidence rates of mult

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Admitted to the medical intensive care unit during the study period.

Exclusion criteria

Exclusion criteria: 1. Aged <18 years 2. Hospitalized <72 hours

Design outcomes

Primary

Measure	Time frame
MRSA acquisition assessed using culture results which were obtained from patients’ nares up to 48 hours after ICU admission and on discharge from ICU.	—

Secondary

Measure	Time frame
1. Vancomycin-resistant Enterococcus spp. (VRE) acquisition assessed by reviewing culture results and medical records from admission until discharge from ICU 2. Multidrug-resistant Acinetobacter baumannii (MRAB) acquisition assessed by reviewing culture results and medical records from admission until discharge from ICU 3. Clostridium-difficile–associated disease (CDAD) acquisition assessed by reviewing culture results and medical records from admission until discharge from ICU 4. Hospital-acquired infections (HAI), including bloodstream infection, pneumonia, and urinary tract infection as defined by The Centers for Disease Control and Prevention, assessed by reviewing culture results and medical records from admission until discharge from ICU	—

Measure

Time frame

1. Vancomycin-resistant Enterococcus spp. (VRE) acquisition assessed by reviewing culture results and medical records from admission until discharge from ICU 2. Multidrug-resistant Acinetobacter baumannii (MRAB) acquisition assessed by reviewing culture results and medical records from admission until discharge from ICU 3. Clostridium-difficile–associated disease (CDAD) acquisition assessed by reviewing culture results and medical records from admission until discharge from ICU 4. Hospital-acquired infections (HAI), including bloodstream infection, pneumonia, and urinary tract infection as defined by The Centers for Disease Control and Prevention, assessed by reviewing culture results and medical records from admission until discharge from ICU

—

Countries

Korea, South

Contacts

Public ContactSu Jin Jeong

JSJ@yuhs.ac.kr+82-2-2228-1986

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 4, 2026