Cataract surgery Eye Diseases Other cataract
Conditions
Interventions
Participants requiring bilateral cataract surgery will be randomised firstly to receive cefuroxime or levofloxacin for their first eye surgery. Their fellow/second eye surgery will subsequently take p
Sponsors
Guys' and St Thomas' Hospital NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing routine cataract surgery attending the ophthalmology outpatient clinic at St Thomas' Hospital 2. Aged 20-100 years 3. Male or female (of non-childbearing potential) 4. Clinically normal corneal and retinal examination 5. Past ocular history - no history of long-term ocular condition, long-term use of ocular medications or ocular surgery 6. Ability to comply with investigation and follow-up schedule 7. Patients must give informed written consent in order to participate in the study. Non-English speakers will be offered an interpreter. All consents will be witnessed.
Exclusion criteria
Exclusion criteria: 1. Unilateral cataract, very dense (brunescent or white) cataracts 2. Significant difference in corneal thickness, endothelial cell count/morphology or macular thickness of greater than 20% at baseline between the two eyes 3. Past ocular history in either eye of: 3.1. Pre-existing ocular conditions (glaucoma, retinal disease, uveitis, corneal disease) 3.2. Previous ocular surgery 3.3. Surgical complications in either eye 4. Diabetes requiring treatment 5. Medications: use of long-term topical eye drops with the exclusion of lubricant drops; use of tamsulosin (known to cause intra-operative floppy iris syndrome) 6. Allergies to fluoroquinolones, cephalosporins 7. Patients unable to give informed consent or are unable to understand the requirements of the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal endothelial cell count; a comparison will be made between pre-operative to post-operative results and between study groups (cefuroxime versus levofloxacin). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Visual acuity 2. Intra-ocular inflammation (flare and cells) 3. Corneal thickness 4. Macular thickness These parameters will be compared from pre-operative to post-operative results and between study groups (cefuroxime versus levofloxacin). | — |
Countries
United Kingdom
Outcome results
None listed