Acute myocardial infarction Circulatory System Acute myocardial infarction
Conditions
Interventions
Participants will be randomised to receive one of the following two treatments:
1. Manual thrombectomy with a thrombus aspiration microcatheter (suction before stenting)
Sponsors
Papworth Hospital NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with ST segment elevation myocardial infarction (STEMI) or new left bundle branch block (LBBB), <12 hours since symptom onset and with partial restoration of coronary artery flow after passage of a guide wire 2. Age 18-100 years 3. Male or female
Exclusion criteria
Exclusion criteria: 1. Patient unable to consent 2. Cardiogenic shock 3. Unfavourable coronary anatomy 4. Surgical disease 5. Baseline Thrombolysis In Myocardial Infarction (TIMI) flow score = 0 6. Contra-indication to adenosine 7. Heart block 8. Severe airways disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Index of Microcirculatory Resistance (IMR) at the end of the PPCI procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Troponin at 12 and 24 hours 2. Cardiac MRI determined infarct size at day 1 and month 3 | — |
Countries
United Kingdom
Outcome results
None listed