Chronic kidney disease Urological and Genital Diseases Renal failure
Conditions
Interventions
This is a multi-centre cross-sectional and prospective longitudinal cohort study. Primary objectives include assessment of Point of Care Creatinine (POC-Cr) accuracy and precision in order to define t
Sponsors
King's College London
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. 18 years of age or older 2. Willing to complete all study procedures 3. Patients undergoing formal nuclear medicine glomerular filtration rate testing (Study A only) 4. Has Chronic Kidney disease (CKD) KDIGO criteria or is at risk of CKD due to heart disease or diabetes as determined by physician (Removed 16/06/2026: Study B only)
Exclusion criteria
Exclusion criteria: 1. Unable or unwilling to give informed consent 2. Any condition which would make finger prick contraindicated e.g. severe skin conditions, bleeding disorder 3. Study A: If formal GFR testing has been requested only because estimated GFR is not considered to reflect true GFR (e.g. liver disease)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured at a single time point: Study A: 1. Estimated glomerular filtration rate (eGFR) measured using Point of care – creatinine (POC-Cr) 2. Formal GFR assessment (Measured GFR (MGFR) and Venous Creatinine) measured using venous creatinine results from the laboratory and the MGFR results from the nuclear medicine department Study B: 1. Test success rate, safety, training time, patient experience and acceptability of serial capillary POC-Cr testing measured on the final visit using SUTAQ questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| Study B: Measured during baseline and final visit: 1. Capillary creatinine measured using Point of care – creatinine (POC-Cr) 2. Venous serum enzymatic creatinine concentrations (serum Cr) measured using venous creatinine results from the laboratory | — |
Countries
England, United Kingdom
Outcome results
None listed