Acute changes in metabolic parameters after bolus fluid treatment in critically ill patients

Evaluating the changes of cardiac output, oxygen and CO2 derived variables and lactate before and after bolus fluid treatment in critically ill patients with suspected hypovolemia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN31590683

Enrollment

100

Registered

2016-06-30

Start date

2015-01-15

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically ill patients with suspected hypovolemia Haematological Disorders Hypovolemia

Interventions

Patients are included in the study if they needed to receive intravenous fluids consisting of 500 ml of colloids or 1000 ml of crystalloids within 30–50 minutes. The decision to administer bolus fluid

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patient treated in ICU 2. Suspicion of hypovolemia that must be treated 3. Available central venous and arterial catheter 4. Available method for cardiac output measurment (thermodilution, doppler)

Exclusion criteria

Exclusion criteria: 1. Aged under 18 year 2. No jugular or subclavian venous catheter and arterial catheter 3. Individuals on whom it is not possible to measure cardiac output 4. Patients receiving extracorporeal membrane oxygenation (ECMO) support 5. Receipt of interventions (i.e. introduction or increase in the dose of inotropes, changes or introduction of mechanical ventilation) within 30 minutes prior to fluid administration

Design outcomes

Primary

Measure	Time frame
1. Oxygen consumption (VO2) is calculated using the formula arterial oxygen content-Venous oxygen content before and after bolus fluid treatment 2. Oxygen delivery (DO2) is calculated using the formula 10CI arterial oxygen content before and after bolus fluid treatment	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Belgium

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026