Continuous vs. intermittent energy restriction and weight loss

The comparative effects of continuous versus intermittent energy restriction (CER and IER respectively) on changes in weight, anthropometry and other cardio-metabolic disease risk markers in a selected cohort of RIO weight loss patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN31465600

Enrollment

200

Registered

2014-01-07

Start date

2014-02-01

Completion date

Unknown

Last updated

2019-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Weight loss in obese individuals Nutritional, Metabolic, Endocrine Obesity

Interventions

Randomised comparison using 200 overweight or obese, male and female participants (100 randomised to each group). The IER leg of this study will be delivered in the form of the Lighte

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy males and females, aged 18-65 2. Body mass index (BMI) > 30

Exclusion criteria

Exclusion criteria: Those who are pregnant or breastfeeding

Design outcomes

Primary

Measure	Time frame
1. Weight 2. Waist circumference	—

Secondary

Measure	Time frame
1. Fasting glucose, lipids and insulin 2. Liver function tests (LFTs), thyroid function tests (TFTs), Hba1c, adiponectin, leptin, C-reactive protein and IGF-1 3. Bio-impedance and blood pressure as well as dietary adherence using validated food diaries	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026