Gingivitis Oral Health Gingivitis
Conditions
Interventions
This study has two phases. Participant are randomly divided to three groups by drawing sealed and opaque envelopes containing the codes (A), (B), (C). The induction of experimental gingivitis will be
Sponsors
University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy gingiva with no evidence of periodontitis 2. Male and females aged between 18 to 28 3. Willing to participate and comply with the objectives of the study
Exclusion criteria
Exclusion criteria: 1. Regular users of antiplaque rinses or the use of oral rinses for 30 days before baseline 2. Antibiotics intake within the previous 2 months 3. Smokers 4. Pregnancy or lactation 5. Systemic diseases or long term medications that influencing gingival conditions 6. Orthodontic appliance 7. Presence of detectable increased attachment loss 8. Chewing khat (flowering plant native to the Horn of Africa and the Arabian Peninsula)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bacteria in sub-gingival plaque is measured using bacteria samples from the participants analyzed using DNA sequencing at baseline and day 21 and 35. | — |
Secondary
| Measure | Time frame |
|---|---|
| For the preventative and treatment stages: 1. Plaque is measured using an index scoring system from 0-3 at baseline and at day 7, 14, 21, 28 and 35 2. Gingival index is measured using an index scoring system from 0-3 at baseline and at day 7, 14, 21, 28 and 35 3. Papilla bleeding is measured using an index scoring system from 1-4 at baseline and at day 7, 14, 21, 28 and 35 | — |
Countries
Yemen
Outcome results
None listed