Mental and Behavioural Disorders Mental and Behavioural Disorders Depression
Conditions
Interventions
1. Reboxetine 4mg bd
2. Paroxetine 20mg
Sponsors
Medical Research Council (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 18-74 years with the more severe depressions in whom the GP and patient have already agreed that antidepressants should be prescribed. We will therefore only include those with a Clinical Interview Schedule - Revised (CIS-R) score of =20, a Beck Depression Inventory (BDI) score of =15 and a diagnosis of International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) depressive episode F32 and F33 (from CIS-R).
Exclusion criteria
Exclusion criteria: Pregnant and breast feeding women, patients with psychotic illness, alchohol or substance abuse problems, patients with medical contraindications to Citalopram or Reboxetine. (June 2006: Exclusion criteria were provided as follows: Potential subjects who have taken antidepressant medication within 2 weeks, who cannot complete self-administered scales, who have a psychosis or major substance or alcohol abuse. The GP will exclude anyone who has medical contraindications or in whom participation in the trial is not appropriate.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck depression inventory total score (BDI) at 6 weeks adjusted for baseline BDI score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed