Renal Chronic kidney disease, Cardiovascular disease Urological and Genital Diseases Chronic kidney disease
Conditions
Sponsors
NHS Greater Glasgow and Clyde (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years 2. Written informed consent 3. CKD - patients with chronic kidney disease recruited from local clinic. eGFR 15 - 30ml/min on recent bloods. 4. ESRD - patients with end stage renal disease recruited from local service. Currently receiving renal replacement therapy 5. HTN - patients with hypertension recruited from local clinic. Normal renal function but diagnosis of hypertension
Exclusion criteria
Exclusion criteria: 1. Known liver disease (alcoholic liver disease, hepatitis, cirrhosis) 2. Known HIV infection 3. Known i.v. drug or alcohol abuse 4. Clinical signs of acute infection 5. Known pregnancy 6. Women of childbearing age are who are at risk of pregnancy 7. Subjects with a history of kidney stones 8. Subjects taking daily vitamin C supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in flow mediated dilatation assessed by brachial artery ultrasound, after saline and after ascorbic acid | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Arterial stiffness assessed by pulse wave analysis using the Sphygmocor system. 2. Biomarkers of oxidative stress both measured after saline and then at 0 and 60 minutes after ascorbic acid: 2.1 Total antioxidant capacity measured by colorimetric assay 2.2 Rate of reactive oxygen species generation measured by electron paramagnetic resonance | — |
Countries
United Kingdom
Outcome results
None listed