The impact of micronutrient supplementation on the health of Zambian adults with particular emphasis on intestinal infection

Conditions

Intestinal innate immunity Nutritional, Metabolic, Endocrine Nutritional supplementation

Kayamba V, Chomba M, Kelly P.

2014-03-252 citations

Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial.

Kelly P, Shawa T, Mwanamakondo S, Soko R, Smith G, Barclay GR, Sanderson IR.

2010-07-0630 citations

10.1186/1471-230x-10-72

Micronutrient supplementation has limited effects on intestinal infectious disease and mortality in a Zambian population of mixed HIV status: a cluster randomized trial.

Kelly P, Katubulushi M, Todd J, Banda R, Yambayamba V, Fwoloshi M, Zulu I, Kafwembe E, Yavwa F, Sanderson IR, Tomkins A.

2008-10-0129 citations

10.1093/ajcn/88.4.1010

Interventions

Randomised, placebo-controlled trial of solid tablet formulation of 15 micronutrients, administered daily, with cross-over after two years. The anticipated end date of this trial has been shortened t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adults (over 18 years of age, either sex) resident within a defined geographical area of Misisi compound, Lusaka, Zambia, have been invited to participate.

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. Frequency of diarrhoeal disease 2. CD4 count in human immunodeficiency virus (HIV) seropositive participants 3. Expression of antimicrobial peptides in small intestinal tissue and secretions 4. Change in micronutrient status	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Zambia

Outcome results

None listed