Cardiovascular diseases: Cerebrovascular disease Circulatory System Stroke
Conditions
Interventions
1. Treatment with intravenous 10% glucose solution, 20 mmol KCL and Actrapid insulin (initial insulin 16 units/500ml) at 100 ml per hour.
2. Control treatment with intravenous N saline
Sponsors
NHS R&D Regional Programme Register - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: All acute stroke patients (less than 24 hours onset) with cerebral infarction (CI) or primary intracerebral haemorrhage (PICH) and admission plasma glucose greater than 6.1 and less than 17 mMol/l.
Exclusion criteria
Exclusion criteria: 1. Subarachnoid haemorrhage 2. Renal failure (urea 320 mMol/l or creatinine 3200 mMol/l) 3. Anaemia (Hb less than 9.0 g/dl) 4. Coma 5. Isolated posterior circulation syndromes with no physical disability 6. Pure language disorders 7. Established history of insulin dependent diabetes mellitus 8. Previous disabling stroke (Modified Rankin score 3) 9. Established diagnosis of dementia or abbreviated mental test score less than 7/10 10. Symptomatic cardiac failure - New York Heart Association (NYHA) Grade 3 or 4
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality at 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with a poor outcome (modified Rankin score 4 - 6) at 12 weeks between treatment groups. | — |
Countries
England, United Kingdom
Outcome results
None listed