Diaphragm palsy Musculoskeletal Diseases
Conditions
Interventions
Examinations (DCR, USS, spirometry) will be completed on the same day where possible, with all investigations performed all at the LHCH site. An interval of up to 48 hours will be considered allowable
Sponsors
Liverpool Heart and Chest Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years 2. Suspected of having a paralysed hemidiaphragm based on suspicious clinical/radiological signs 3. Able to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Potentially pregnant or lactating 2. Refusal or inability to provide informed consent 3. Unable or unwilling to sit or stand to perform DCR in the radiology department 4. Unable or unwilling to follow breathing instructions (for example, holding their breath) 5. Unable to perform reproducible spirometry and/or full pulmonary function studies within ATS-ERS criteria 6. Any serious or active medical or psychiatric illness, which in the opinion of the investigators, would interfere with subject treatment, assessment, or compliance with the protocol 7. Involved, either currently or recently, in other studies involving non-routine exposure to sources of ionising radiation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragm distance (excursion) and speed are measured by both DCR and ultrasound during sniff manoeuvres | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The postural change in FVC detected on lying/standing spirometry and the lung volumes calculated by DCR. 2. Comparison between diaphragm excursion/speed between 15 and 6 frame per second DCR. | — |
Countries
England, United Kingdom
Contacts
Public ContactThomas FitzMaurice
Outcome results
None listed