Severe acute malnutrition Nutritional, Metabolic, Endocrine Unspecified protein-energy malnutrition
Conditions
Interventions
Current information as of 02/02/2009:
In 36 children, ciprofloxacin will be given 2 hours after the child has received his/her first feed and medication. 16 children will have ciprofloxacin administer
Sponsors
Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme (Kenya)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 6 months, either sex 2. Consent given 3. Severe malnutrition as defined by weight-for-height Z score (WHZ) less than -3 or bilateral oedema (of kwashiorkor) or mid-upper arm circumference (MUAC) less than 11.0 cm (if greater than 65 cm in length) 4. Able to take and retain oral treatment
Exclusion criteria
Exclusion criteria: 1. Admission plasma creatinine greater than 300 and evidence of intrinsic renal disease (hypertension or hyperkalaemia) 2. Coexisting bone or joint disease 3. Concurrent use of antacids, ketoconazole, theophylline, corticosteroids 4. Enrolment in another interventional study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the peak plasma concentrations of ciprofloxacin. Measured: Group 1: at 2, 4, 8, 24 hours Group 2: at 3, 5, 9, 12 hours Group 3: at 1, 3, 6, 10 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Define which co-variates influence the pharmacokinetics of ciprofloxacin in this group of patients: 1. Age, assessed on admission (0 hour) 2. Sex, assessed on admission (0 hour) 3. Anthropometric indices, assessed on admission (0 hour) 4. Haemodynamic status, measured at 0 hour and 48 hour 5. Concomitant medications, reviewed every 4 hours | — |
Countries
Kenya
Outcome results
None listed