Neuropsychological problems in children who finished treatment for a primary brain tumor Mental and Behavioural Disorders
Conditions
Interventions
In this RCT, participants and their parents will be randomized using an online tool to the individualized intervention arm or standardized intervention arm. Participants will be blinded to their treat
Sponsors
Princess Máxima Center
Eligibility
Sex/Gender
All
Age
8 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Age between 8-17 years old 2. Diagnosed with a primary brain tumor 3. Completed treatment for a primary brain tumor (patients who are considered “wait and see” and have not received treatment will also be eligible) 4. Experiencing cognitive problems (=1SD below normative mean or estimated IQ [EIQ]) on =2 scores, including WISC-V/WAIS-IV, IDS2, CPT3, 15WT tests and/or self- or proxy-reported PedsQL Fatigue or BRIEF-2 questionnaires) 5. A parent/caregiver who they have regular contact (in order to participate in the intervention with them)
Exclusion criteria
Exclusion criteria: 1. No signed informed consent (either by patient and/or parents/legal guardian) 2. Cannot complete neuropsychological assessment or questionnaires because they do not speak/understand the Dutch language 3. Currently receiving palliative/end-of-life care 4. Currently receiving other neuropsychological treatment 5. Severe developmental or psychiatric disorders and thus alternative interventions would be needed (e.g., autism spectrum disorder, schizophrenia, major depressive disorder) 6. Significant sensory, motor, or developmental problems and thus alternative neuropsychological assessments would be needed (i.e., blindness, deafness, profound developmental delay FSIQ <55) 7. Treating physician or psychologist advises against inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Goal attainment is measured using Goal Attainment Scaling (GAS) at baseline, 3 months and 12 months follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neuropsychological assessment tasks: 1.1 Estimated Intelligent Quotient (IQ) measured using the Vocabulary and Matrix Reasoning subtests from Weschler Intelligence Scale for Children-V (WISC-V)/Weschler Adult Intelligence Scale-IV (WAIS-IV) at baseline and 12 months follow-up 1.2 Working memory measured using the Digit Span from WISC-V/WAIS-IV at baseline and 12 months follow-up 1.3. Processing speed measured using the Coding from WISC-V/WAIS-IV at baseline and 12 months follow-up 1.4. Executive functioning measured using the subtests Road Walking from the Intelligence and Development Scales-2 (IDS-2) at baseline and 12 months follow-up 1.5. Memory measured using Rey Auditory Verbal Learning Test (RAVLT) at baseline and 12 months follow-up 1.6. Sustained attention measured using Continuous Performance Test-3 (CPT-3) at baseline and 12 months follow-up 1.7 Social functioning measured using IDS-2 Socially Competent Behavior task at baseline and 12 months follow-up 2. Questionnaires filled out by parents and/or patients: 2.1 Adaptive behavior measured by the Adaptive Behavior Assessment System – Third Edition (ABAS-3) at baseline, 3 months and 12 months follow-up 2.2 Executive functioning in daily life measured by the Behavior Rating of Executive Function-2 (BRIEF-2) at baseline, 3 months and 12 months follow-up 2.3 Fatigue measured by the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL-MFS) at baseline, 3 months and 12 months follow-up 2.4 Emotional problems measured by the Patient-Reported Outcomes Measurement Information System (PROMIS) Anxiety and Depressive Symptoms Short Forms 3.0 at baseline, 3 months and 12 months follow-up 2.5 Social functioning measured by the PROMIS Peer Relationships short form 3.0 at baseline, 3 months and 12 months follow-up 2.6 Parental stress measured by the Distress Thermometer for Parents (DT-P) at baseline, 3 months and 12 months follow-up 2.7 Socioeconomic status, birth, developmental, psychiatric, | — |
Countries
Netherlands
Contacts
Public ContactMarita Partanen
Outcome results
None listed