Passive immunity against weapon of bioterrorism Digestive System
Conditions
Interventions
Fifteen participants (9 women and 6 men) were enrolled in this study. Volunteers received capsules of the freeze-dried putative probiotics (L. gasseri 177, L. acidophilus 821-3, L. gasseri E16B7, L. p
Sponsors
Estonian Science Foundation (Estonia)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Both males and females, aged 20 - 70 years 2. Wish to participate in the study 3. Healthy (i.e. no known health problems and no medical conditions that require drug therapy) 4. Informed consent obtained
Exclusion criteria
Exclusion criteria: 1. History of any gastrointestinal disease 2. Use of any antimicrobial drug within last month 3. Use of any regular concomitant medication, including medical preparations 4. Pregnancy/breastfeeding 5. Food allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. No adverse effect after consumption according to clinical, blood and intestinal indices. Timepoints of assessment: at recruitment and end of the study (day 20). 2. The best coloniser from the five tested Lactobacillus strains was detected at the end of the study (day 20) | — |
Secondary
| Measure | Time frame |
|---|---|
| Colonisation by L. acidophilus 821-3 confirmed by real time polymerase chain reaction (PCR) in faecal samples at the end of the study (day 20) | — |
Countries
Estonia
Outcome results
None listed