The effect of low or high saturated fat ketogenic diet on lipidemia Nutritional, Metabolic, Endocrine
Conditions
Interventions
A randomized parallel clinical trial will be conducted for 4 weeks to assess the impact of high and low saturated fat KD (SFKD) on lipid profile and microbiota of healthy lean and obese participant
Sponsors
University of Aberdeen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 60 years 2. Male or female participants 3. Lean group: BMI between 18.5 and 24.9 kg/m² 4. Obese group: BMI above 29.9 kg/m² 5. Willingness to adhere to the assigned diet for the duration of the study 6. Ability to provide informed consent 7. No use of lipid-lowering medication 8. No use of blood pressure medication
Exclusion criteria
Exclusion criteria: 1. For lean participants, elevated lipid profile defined by total cholesterol above 5.2 mmol/L and LDL above 3.5 mmol/L with triglyceride HDL ratio between 4.0 to 6.0. For obese participants, total cholesterol above 6 mmol/L and LDL above 5 mmol/L 2. Cardiovascular diseases 3. Eating disorder 4. Diagnosed with hypertension (above 140/90 mmHg) and taking blood pressure medications such as ACE inhibitors, calcium channel blockers, or diuretics 5. Being pregnant 6. Food allergies 7. Inflammatory bowel disease 8. Irritable bowel syndrome 9. Non-alcoholic fatty liver
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profile from baseline (Week 1) and (week 4) though blood samples | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Triglyceride, HDL, glucose,and insulin sensitivity will be measured by blood sample at baseline (week 1) and at (week 4) 2. Gut microbiome activity and composition will be through stool sample collection from week 1 and week 4 3. Body composition measured using DEXA at week 1 and week 4. For blood pressure it will be measured at week 1 and week 4 | — |
Countries
Kuwait
Contacts
Public ContactHebah Ben Salamah
Outcome results
None listed