Patients with inflammatory bowel disease in acute and chronic stage Digestive System Noninfective inflammatory bowel disease, Crohn's disease, ulcerative colitis
Conditions
Interventions
Participants are categorized into acute or chronic stage based on IBD activity scores (Crohn's Disease Activity Index and Simple Clinical Colitis Activity Index). Each participant receives a CMR scan
Sponsors
Charité - University Medicine Berlin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >18 years 2. Clinically, radiologically, and histologically confirmed diagnosis of inflammatory bowel disease 3. No absolute MRI contraindications 4. Able to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Contraindications for MRI scan 2. Pregnancy 3. Known allergy to MRI contrast agent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diffuse or focal fibrosis measured using T1-Mapping, ECV, and late gadolinium enhancement MRI scans at baseline, 5 weeks, and 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ventricular function measured using MRI cine imaging at baseline, 5 weeks, and 1 year 2. Edema quantification using T2-Mapping MRI scans at baseline, 5 weeks, and 1 year 3. Extracellular volume quantification using T1-Mapping post-contrast agent application MRI scans at baseline, 5 weeks, and 1 year | — |
Countries
Germany
Outcome results
None listed