UK Study of magnetic resonance imaging (MRI) for breast screening

National multicentre study of magnetic resonance imaging (MRI) as a method of screening for breast cancer in women at genetic risk

Status

Active, not recruiting

Phases

Phase 3

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN30587563

Enrollment

900

Registered

2010-06-18

Start date

1997-04-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: National Cancer Research Network

Interventions

A symptomatic cohort will be measured in the first year to establish common criteria for scoring and to ensure consistent practice. Women will be followed up to ascertain the true rate of breast cance

Eligibility

Inclusion criteria

Inclusion criteria: Group 1: 1. Women aged 35 - 49 years 2. Tested BRCA1 or BRCA2 carriers 3. Known mutation in first degree relative 4. Family history of breast and ovarian cancer (four or more relatives) Group 2: 1. Women aged 25 - 49 years 2. Tested p53 carriers 3. Known mutation in a first degree relative 4. Family history consistent with Li Frameni syndrome

Exclusion criteria

Exclusion criteria: 1. Previous breast cancer (including ductal carcinoma in situ [DCIS]) 2. Terminal illness, or life expectancy of less than 5 years 3. Pregnancy or breast-feeding (recruitment suspended until breast-feeding has finished) 4. Current chemotherapy (recruitment suspended until 6 months after treatment ceases; exclusion 2, above, still applies)

Design outcomes

Primary

Measure	Time frame
Annual MRI and x-ray breast examination	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026