Cervical intraepithelial neoplasia [CIN], grade II Urological and Genital Diseases Cervical intraepithelial neoplasia [CIN], grade II
Conditions
Interventions
If enrolled on the study after CIN2 diagnosis:
1. Primary visit for colposcopy – CIN2 identified, acetowhite photograph and Patch taken followed by biopsy
2. 3-month visit for colposcopy – Patch, ace
Sponsors
Cambridge University Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: All patients who are <35 years of age AND are CIN2 positive on biopsy AND have only single quadrant disease
Exclusion criteria
Exclusion criteria: 1. Patients >35 years 2. Patients who are pregnant 3. Patients who are immunosuppressed/are HIV positive 4. Patients who cannot give informed consent 5. Patients who are allergic to nail varnish/have been told they are allergic to nitrocellulose
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. CIN2 lesions identified using colposcopy/cytology/histology and cell lift at 0 months (colposcopy cell lift and biopsy), 3 months (colposcopy and cell lift), 6 months (colposcopy, cytology and cell lift), 9 months (colposcopy and cell lift), and 12 months colposcopy cell lift and biopsy) 2. Biomarker patterns consistent with lesion regression/progression identified using immunohistochemistry at 0, 3, 6, 9 and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Outcome results
None listed