A study to investigate how common a diagnosis of axial spondyloarthritis (axSpA) is in patients with known inflammatory bowel disease (IBD) such as Crohn’s Disease and Ulcerative Colitis, and the development of a tool to direct referral of patients with suspected axSpA in IBD patients to a rheumatology specialist.

Axial Spondyloarthritis in Inflammatory Bowel Disease – secondary care cross-sectional prevalence and development of an evidence-base referral tool [Norfolk - Axial SPa Ibd REferral Tool (N-ASPIRE Tool)]

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN30265575

Enrollment

390

Registered

2018-04-20

Start date

2018-05-01

Completion date

Unknown

Last updated

2022-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Axial Spondyloarthritis / Ankylosing Spondylitis Musculoskeletal Diseases Axial Spondyloarthritis / Ankylosing Spondylitis

Interventions

Patients with a known diagnosis of IBD attending gastroenterology appointments are invited to participate in the study via a postal questionnaire. If patients are deemed eligible, participants are inv

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria for Phase 1 (Screening): 1. Gastroenterologist verified diagnosis of inflammatory bowel disease (Crohn’s disease or Ulcerative colitis, with either endoscopic, radiological or histological evidence of disease based on established criteria) 2. Age = 18 and = 80 years old 3. Patient willing and able to participate in the study 4. Including known/previous diagnosis of AS or axSpA Inclusion criteria for Phase 2 (Clinical assessment): 1. Chronic back pain (= 3 months) 2. Onset of back pain before 45 years old 3. Including known/previous diagnosis of AS or axSpA (if unable to verify diagnosis retrospectively)

Exclusion criteria

Exclusion criteria: 1. Any type of biologic therapy for (previous or current) treatment of IBD 2. Unable to tolerate MRI scanning (e.g. current history of claustrophobia) or contra-indication to MRI scanning (including but not limited to e.g. pacemaker, pregnancy, metallic or conducting foreign body, etc.) 3. Age 80 years 4. Patients lacking in capacity and/or unable to give informed consent 5. Patients unable to understand English to sufficient degree to be able to complete a questionnaire 6. Illiteracy 7. Prisoners 8. Patient unwilling to take part in the study

Design outcomes

Primary

Measure	Time frame
1. Total number of participants given a physician verified diagnosis of axial spondyloarthritis is recorded at the assessment. 2. Number of participants given a new physician verified diagnosis of axial spondyloarthritis is recorded at the assessment. 3. The sensitivity and specificity of the N-ASPIRE referral tool is assessed using positive and negative predictive values including likelihood ratios and diagnostics odd ratio.	—

Measure

Time frame

1. Total number of participants given a physician verified diagnosis of axial spondyloarthritis is recorded at the assessment. 2. Number of participants given a new physician verified diagnosis of axial spondyloarthritis is recorded at the assessment. 3. The sensitivity and specificity of the N-ASPIRE referral tool is assessed using positive and negative predictive values including likelihood ratios and diagnostics odd ratio.

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Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026