Rabies vaccine Infections and Infestations Rabies
Conditions
Interventions
220 healthy volunteers in the UK between the ages of 18 and 50 years will be recruited and randomised into one of four treatment groups of 55 people each. The standard intramuscular rabies post-exposu
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers in Oxfordshire between the ages of 18 and 50 years, either sex 2. Have never had rabies vaccine before 3. Able to attend all appointments
Exclusion criteria
Exclusion criteria: 1. Any previous rabies immunisation 2. Treatment with human immunoglobulins or blood transfusion within the past three months 3. The use of immunosuppressive drugs 4. Pregnancy 5. Uncertainty about returning for appointments during the year 6. Chloroquine cannot be taken for two weeks prior to vaccination at day zero until two weeks after vaccination at day 90
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples are taken to measure the level of rabies virus-neutralising antibody by the Rabies antibody responses (RIFFIT) method. The serological results of the test regimen will be compared with those of control reference regimens of proven clinical efficacy. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed