Kidney transplantation Injury, Occupational Diseases, Poisoning Complications following infusion, transfusion and therapeutic injection
Conditions
Interventions
The trial will test whether a simple procedure, the application of a blood pressure cuff to the arm of the donor and the recipient before a kidney transplant, can help protect the donor kidney from th
Sponsors
University College London (UCL) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing living donor transplantation 2. Patients aged 18 years and above, either sex
Exclusion criteria
Exclusion criteria: 1. 0,0,0-mismatched renal grafts (no mismatch in HLA-A/B/DR antigens between donor and recipient) 2. Patients on adenosine triphosphate (ATP)-sensitive potassium channel opening or blocking drugs 3. Patients on ciclosporin 4. Patients who have had a previous transplant 5. Patients with a known iodine sensitivity (who cannot undergo iohexol clearance studies) Added 04/08/2010: 6. Patients with ABO incompatability 7. Any patient requiring HLA antibody removal therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate (GFR) 12 months after transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rate of fall in creatinine in the first 72 hours after transplantation 2. Inflammatory response to surgery in the first 5 days after transplantation 3. Protein expression in kidney parenchyma samples using histochemistry 4. Protein activation and expression in renal vasculature using immunoblotting 5. Kidney fibrosis 6 months after transplantation 6. Alloreactivity of T-cells in the first 18 months after transplantation 7. Patient outcomes 2 - 5 years after transplantation using renal registry data | — |
Countries
Netherlands, United Kingdom
Outcome results
None listed