National randomised trial of hormone replacement therapy (HRT) in women with a history of early stage breast cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN29941643

Enrollment

3000

Registered

2001-07-01

Start date

2003-08-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer Breast

Interventions

1. HRT 2. No HRT (advice about non-hormonal alternatives) Trial was closed early (December 2005) due to poor recruitment.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Patients must have had proven stage I/II breast cancer with no clinical evidence of recurrence since diagnosis 2. Have been given a patient information pack 3. Be postmenopausal as defined by: a. Having been amenorrhoeic for at least 6 months (including women who have had radiation or chemical induced ovarian suppression) irrespective of menopausal status at time of diagnosis b. Having received surgical bilateral oophorectomy c. Be experiencing vasomotor symptoms (i.e. hot flushes or night sweats) with or without vaginal dryness. All such women are eligible irrespective of current/previous treatment for breast cancer.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Not provided at time of registration	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026