The relationship between body fat and long-term clinical outcome in anorexia nervosa

The relationship between body fat and long-term clinical outcome in anorexia nervosa: a longitudinal study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN29929022

Enrollment

Registered

2014-10-31

Start date

2012-01-01

Completion date

Unknown

Last updated

2020-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia nervosa/body composition Mental and Behavioural Disorders

Interventions

We recruited 55 female patients with a diagnosis of anorexia nervosa for an observational study. The interventions are weight restoration and inpatient cognitive behavioural therapy. All patients rece

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Female patients aged 18?45 years 2. Diagnosis of anorexia nervosa 3. BMI =18.5 kg/m² at time zero 4. BMI = 18.5 kg/m² at the end of the treatment

Exclusion criteria

Exclusion criteria: 1. Participants that do not satisfy inclusion criteria. 2. Participants with active substance abuse, schizophrenia and other psychotic disorders

Design outcomes

Primary

Measure	Time frame
Assessing whether lower percent total body fat predict long-term relapse. Clinical outcome was determined using: 1. Morgan-Russell criteria: 1.1. Full outcome: No DSM criteria for anorexia nervosa for a minimum of eight weeks 1.2. Good outcome: BMI = 18.5 kg/m², normal menses, may have some binge eating or purging behavior or psychological symptoms of anorexia nervosa 1.3. Fair outcome: BMI = 18.5 kg/m²; amenorrhea 1.4. Poor outcome: BMI < 18.5 kg/m² 2. Eating Disorder Examination Interview: 2.1. Full outcome: BMI =18.5 kg/m² and EDE total score < 1.74 2.2. Good outcome: BMI = 18.5 kg/m² 2.3. Poor outcome: BMI < 18.5 kg/m² *Outcome was dichotomized into 'full, good or fair' and 'poor'. Evaluated at the end of one year follow-up.	—

Measure

Time frame

Assessing whether lower percent total body fat predict long-term relapse. Clinical outcome was determined using: 1. Morgan-Russell criteria: 1.1. Full outcome: No DSM criteria for anorexia nervosa for a minimum of eight weeks 1.2. Good outcome: BMI = 18.5 kg/m², normal menses, may have some binge eating or purging behavior or psychological symptoms of anorexia nervosa 1.3. Fair outcome: BMI = 18.5 kg/m²; amenorrhea 1.4. Poor outcome: BMI < 18.5 kg/m² 2. Eating Disorder Examination Interview: 2.1. Full outcome: BMI =18.5 kg/m² and EDE total score < 1.74 2.2. Good outcome: BMI = 18.5 kg/m² 2.3. Poor outcome: BMI < 18.5 kg/m² *Outcome was dichotomized into 'full, good or fair' and 'poor'. Evaluated at the end of one year follow-up.

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Secondary

Measure	Time frame
Assessing whether higher percent trunk fat may predict long-term relapse. Clinical outcome was determined using: 1. Morgan-Russell criteria: 1.1. Full outcome: No DSM criteria for anorexia nervosa for a minimum of eight weeks 1.2. Good outcome: BMI = 18.5 kg/m², normal menses, may have some binge eating or purging behavior or psychological symptoms of anorexia nervosa 1.3. Fair outcome: BMI = 18.5 kg/m²; amenorrhea 1.4. Poor outcome: BMI < 18.5 kg/m² 2. Eating Disorder Examination Interview: 2.1. Full outcome: BMI =18.5 kg/m² and EDE total score < 1.74 2.2. Good outcome: BMI = 18.5 kg/m² 2.3. Poor outcome: BMI < 18.5 kg/m² *Outcome was dichotomized into 'full, good or fair' and 'poor'. Evaluated at the end of one year follow-up.	—

Measure

Time frame

Assessing whether higher percent trunk fat may predict long-term relapse. Clinical outcome was determined using: 1. Morgan-Russell criteria: 1.1. Full outcome: No DSM criteria for anorexia nervosa for a minimum of eight weeks 1.2. Good outcome: BMI = 18.5 kg/m², normal menses, may have some binge eating or purging behavior or psychological symptoms of anorexia nervosa 1.3. Fair outcome: BMI = 18.5 kg/m²; amenorrhea 1.4. Poor outcome: BMI < 18.5 kg/m² 2. Eating Disorder Examination Interview: 2.1. Full outcome: BMI =18.5 kg/m² and EDE total score < 1.74 2.2. Good outcome: BMI = 18.5 kg/m² 2.3. Poor outcome: BMI < 18.5 kg/m² *Outcome was dichotomized into 'full, good or fair' and 'poor'. Evaluated at the end of one year follow-up.

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Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026