Normal Pressure Hydrocephalus (NPH) Nervous System Diseases Normal Pressure Hydrocephalus (NPH)
Conditions
Interventions
Treatment group: Endoscopic third ventriculostomy and choroid plexus coagulation.
Control group: Programmable (Codman Medos valve) ventriculoperitoneal shunt.
Sponsors
The Frenchay Hydrocephalus Research Fund (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. A clinical diagnosis of Normal Pressure Hydrocephalus (NPH) by the following criteria: a. Evidence of significant gait disturbance in the absence of other causative factors b. Evidence of some cognitive impairment on formal neuropsychological testing (Mattis dementia rating scale and Folstein mini-mental state examination) and/or urinary incontinence or evidence of neurogenic urinary disturbance (frequency or urgency) c. Lumbar Opening Pressure less than 20 mmHg on supine lumbar puncture 2. Symptom duration of more than six months 3. Evidence of disease progression since onset of symptoms 4. Radiological evidence of hydrocephalus, Evans ratio more than 0.3 on Computed Tomography (CT) scan of head 5. Patients must be fit enough to undergo operative surgical treatment, as defined by an American Society of Anesthesiologists (ASA) score of one, two or three 6. Written informed consent to participation in the study obtained from the patient, or next of kin if the patient is unable (due to cognitive impairment) to give informed consent
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed