Specialty: Cancer, Primary sub-specialty: Sarcoma
Conditions
Interventions
Participants are approached to donate blood samples (up to 20ml) which are immediately transported to Newcastle University for analysis at the following time points:
1. At diagnosis
Sponsors
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with a suspected bone sarcoma (any gender and age range 4 to 80 years old) OR 2. Patients with a confirmed diagnosis of a bone sarcoma (any gender and age range 4 to 80 years old)
Exclusion criteria
Exclusion criteria: 1. Patients (or their parent/guardian for those under the age of 16) who are unable to give informed consent 2. Prisoners 3. Patients who are pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Enumeration of circulating tumour cells is assessed using flow cytometry at diagnosis, during treatment stages and on completion of treatment to assess for changes in the circulating tumour cell counts. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlation of circulating tumour cell number measured by flow cytometry at diagnosis and subsequent treatment stages up to 5 years 2. Genomic analysis is undertaken using next generational sequencing at diagnosis and subsequent treatment stages up to 5 years | — |
Countries
England, Scotland, United Kingdom
Contacts
Public ContactKenneth Rankin
Outcome results
None listed