Liver tumour Cancer Malignant neoplasm of the liver
Conditions
Interventions
All patients will receive intrahepatic microdialysis catheters intra-operatively. Pringle manoeuvre means closure of the portal pedicle. The treatment arm will begin surgery with 10 minutes of Pringle
Sponsors
The Bengt Ihre Foundation (Sweden)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged greater than 17 years of age (either sex) 2. Suspected malignant tumour in the liver 3. Assigned to curative liver resection of more than one liver segment
Exclusion criteria
Exclusion criteria: 1. Synchronous resection of another hollow viscus 2. Jaundice (bilirubin greater than 60 mM) 3. Ongoing infection 4. Child's B or worse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Changes in metabolism (anaerobic/aerobic), studied with microdialysis 2. Ischaemia-reperfusion injury (histology, myeloperoxidase [MPO], etc) Results of the microdialysis samples are recorded continuously for 5 days post-operatively (and blood samples daily for 5 days), but data are not compiled and analysed until the last study participant has completed the 30-day follow-up time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Extent of the resected liver volume, recorded continuously and the volume of resection will be recorded immediately after the operation. Data are not compiled and analysed until the last study participant has completed the 30-day follow-up time. | — |
Countries
Sweden
Outcome results
None listed