Reduced antibiotic use and hospital stay in newborns with sepsis after implementation of new guidelines

C-reactive protein- and clinical symptoms-guided strategy in term neonates with early-onset sepsis reduced antibiotic use and hospital stay

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN29535824

Enrollment

237

Registered

2020-05-28

Start date

2016-01-01

Completion date

Unknown

Last updated

2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early-onset sepsis in term neonates Neonatal Diseases

Interventions

The intervention includes new treatment guidelines introduced on 11 June 2018. The researchers decided a priori to evaluate the guidelines by comparing data from 24 months before and 15-16 months afte

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Term neonates in gestational week 37 + 0 to week 41 + 6 2. Clinically diagnosed as early-onset sepsis that had initiated antibiotic treatment within 72 h of life

Exclusion criteria

Exclusion criteria: Term neonates who received prophylactic antibiotic treatment and not because of early-onset sepsis

Design outcomes

Primary

Measure	Time frame
The number of days with antibiotic treatment, collected retrospectively from medical records for Period 1 between 1 January 2016 and 31 December 2017 and period 2 between 11 June 2018 and 30 September 2019	—

Secondary

Measure	Time frame
1. Reinfection or readmission to hospital within 3 days after completed antibiotic treatment 2. Hospital stay 3. Healthcare costs calculated based on the cost per day of care Data collected retrospectively from medical records for Period 1 between 1 January 2016 and 31 December 2017 and period 2 between 11 June 2018 and 30 September 2019	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 25, 2026