Prevention of early adverse cardiovascular remodelling in children born to obese mothers Circulatory System
Conditions
Interventions
The original UPBEAT RCT involved obese pregnant women who were randomized in early pregnancy to a behavioural intervention (diet and physical activity) or to standard antenatal care.
The Children of
Sponsors
King's College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Women who took part in UPBEAT during their pregnancy and their 9-11-year-old children
Exclusion criteria
Exclusion criteria: 1. Inability and unwillingness to provide informed consent 2. Any major health problems which may impact the development of the cardiovascular system or body composition 3. Women and their children who did not take part in the previous UPBEAT study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 09/04/2025: Interventricular septal wall thickness using transthoracic echocardiography at a single timepoint _____ Previous primary outcome measure: Left ventricular mass measured using transthoracic echocardiography at a single timepoint | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured at a single timepoint: 1. Blood pressure and heart rate variability measured during clinical visits and by ambulatory monitors over 24 hours 2. Cardiac structure and function measured using transthoracic echocardiography 3. Arterial stiffness measured using pulse-wave velocity 4. Carotid intima-media thickness measured using vascular ultrasound 5. Body composition analysis measured using dual-energy X-ray absorptiometry (DEXA) and anthropometry 6. Cardiorespiratory fitness estimated using a sub-maximal fitness test | — |
Countries
England, Scotland, United Kingdom
Outcome results
None listed