A randomised controlled placebo based trial to determine the efficacy of a prophylactic dose of hydrocortisone and anti histamine in preventing reactions to anti snake venom (ASV)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN29425449

Enrollment

250

Registered

2005-09-29

Start date

2005-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaphylactoid and pryogenic reactions to anti snake venom Injury, Occupational Diseases, Poisoning Reactions to anti snake venom

Interventions

Either a placebo or 100 mg of hydrocortisone and 10 mg of H1 anti histamine will be administered once reqirement for ASV has been established. All outcomes will be monitored. In the event of an advers

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Snakebite with systemic symptoms 2. Requirment for ASV 3. Have given consent

Exclusion criteria

Exclusion criteria: History of severe atopic diseases

Design outcomes

Primary

Measure	Time frame
Number of anaphyalactoid and pyrogenic reactions	—

Secondary

Measure	Time frame
Severity of reaction	—

Countries

India

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026