Skin cancer prevention Cancer Other malignant neoplasms of skin
Conditions
Interventions
5 x 1 g capsules to be taken with breakfast
Control (placebo): medium chain triglyceride oil (GTCC, Croda, UK)
5 x 1 g capsules to be taken with breakfast
For each volunteer, the duration of nutritional supplementation is 12 weeks
follow-up is 2 weeks.
Active: fish oil supplements rich in n-3 PUFAs (Incromega E7010 SR, Croda, UK)
Sponsors
University of Manchester (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female 2. Aged 18 - 60 years 3. Sun reactive skin type 1 or 2 4. Reporting allergy to jewellery with nickel content
Exclusion criteria
Exclusion criteria: 1. History of atopy 2. History of skin cancer 3. History of a photosensitivity disorder 4. Sunbathing in the past 3 months 5. Pregnancy 6. History of cardiac disease 7. Taking of photoactive medication 8. Not able to eat fish or gelatin 9. Taking fish oil supplements prior to the study 10. Consuming more than 3 meals containing oily fish per week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine the protective effect of n-3 PUFA on: 1. UVR-induced suppression of clinical CHS responses using the International Contact Dermatitis Research Group (ICDRG) grading scale: No reaction (-) to extreme positive (+++) 2. UVR-induced modulation of immune cells (epidermal Langerhans cells) using immunohistochemistry of epidermal sheets Assessed simultaneously at 13 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of immunoregulatory mediators in the skin using mass spectrometry analysis and Luminex analysis of cytokine expression in suction blister fluid. Assessed simultaneously at 13 weeks. | — |
Countries
United Kingdom
Outcome results
None listed