Metabolic syndrome and cardiovascular disease risk Circulatory System Other metabolic disorders
Conditions
Interventions
low fat, low GI) with a control group (SFA intake typical of the UK habitual diet)
high MUFA, low GI
low fat, high GI
Comparison of four experimental diets (high MUFA, high glycemic index [GI]
Sponsors
MRC Human Nutrition Research (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Males and females, 30-70 years and at higher metabolic risk (based on a composite scoring system for metabolic syndrome features).
Exclusion criteria
Exclusion criteria: 1. History of the following conditions/treatments 1.1. myocardial infarction 1.2. cancer 1.3. diabetes mellitus 1.4. cholestatic liver disease or pancreatitis 1.5. chronic coronary, renal or bowel disease 1.6. gastrointestinal disorders 1.7. hypolipidemic therapy 1.8. systemic corticosteroids 1.9. androgens 1.10. phenytoin 1.11. erythromycin 1.12. heamostatic drugs (excluding aspirin) 2. Smokers >20/day 3. History of substance abuse or alcoholism 4. Pregnancy, planning pregnancy or 12-months post-partum 5. Allergy or intolerance to study foods 6. Recent weight change 7. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) >1 g/day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin sensitivity from measures of glucose and insulin during an intravenous glucose tolerance test. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Fasting lipid profile 2. Vascular reactivity and endothelial function 3. Haemostatic factors 4. Markers of the inflammatory response 5. Leptin and adiponectin 6. Urinary microalbumin to creatinine ratio 7. Plasma fatty acid composition 8. DNA for nutrient-gene interactions | — |
Countries
United Kingdom
Outcome results
None listed