A study comparing home treatment of COPD exacerbations to usual hospital care

Randomised controlled trial of hospital at home compared to standard inpatient management of patients with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD), triaged for hospital admission by Accident and Emergency and with low mortality risk according to the novel DECAF score

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN29082260

Enrollment

118

Registered

2014-06-02

Start date

2014-06-04

Completion date

Unknown

Last updated

2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease Respiratory

Interventions

Patients will be allocated to hospital at home (HAH) or usual care. Whilst receiving hospital at home, the patient will remain under the care of the hospital team, with 24/7 on-call support. Home trea

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =35 years 2. Smoking history =10 pack years 3. Obstructive spirometry (FEV1/ VC <70%) 4. Primary diagnosis of AECOPD 5. DECAF score 0 or 1

Exclusion criteria

Exclusion criteria: Current exclusion criteria as of 26/09/2014: 1. Other illness likely to limit survival to 24 hours after admission 6. Lack of ability to give informed consent

Design outcomes

Primary

Measure	Time frame
Health and social care costs over 90 days: non-inferiority analysis.	—

Secondary

Measure	Time frame
1. Survival 2. All cause and respiratory readmission rates 3. Bed days over: a) acute period of care; b) post-discharge to 90 days 4. Carer and patient preference 5. COPD Exacerbations 6. Unplanned health resource use: emergency hospital visits, unscheduled contact with the respiratory specialist nursing team, community based nurse or GP 7. Hospital anxiety and depression score 8. Quality-of-life: COPD Assessment Tool (CAT) and EQ-5D 9. Zarit Burden Interview (carers) 10. Perceptions of healthcare of patients and their carers and health professionals with regards to the use of the DECAF score for allocation to HAH	—

Measure

Time frame

1. Survival 2. All cause and respiratory readmission rates 3. Bed days over: a) acute period of care; b) post-discharge to 90 days 4. Carer and patient preference 5. COPD Exacerbations 6. Unplanned health resource use: emergency hospital visits, unscheduled contact with the respiratory specialist nursing team, community based nurse or GP 7. Hospital anxiety and depression score 8. Quality-of-life: COPD Assessment Tool (CAT) and EQ-5D 9. Zarit Burden Interview (carers) 10. Perceptions of healthcare of patients and their carers and health professionals with regards to the use of the DECAF score for allocation to HAH

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 24, 2026