Subcutaneous oxytocin administration before a surgical incision to reduce pain

Effect of local infiltration with oxytocin on hemodynamic response to surgical incision and postoperative pain in patients having laparoscopic surgery under general anesthesia. A randomized, double blind, clinical trial.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN29008609

Enrollment

Registered

2018-11-19

Start date

2016-02-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparascopic surgery, hemodynamic nociceptive automatic response and post-surgical pain Surgery Laparascopic surgery, hemodynamic nociceptive automatic response and post-surgical pain

Interventions

All patients receive standardised anesthetic induction and mantainence. The patients are randomly assigned to one of three groups using block randomization: 1. The oxytocin group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 2. ASA (American Society of Anesthesiologists) Hazard Scale I or ASA II 3. Undergoing scheduled laparoscopic surgery

Exclusion criteria

Exclusion criteria: 1. ASA III or more 2. Emergency surgery 3. Hemodynamic instability 4. Surgical complications (bleeding, intestinal injury) 5. Taking inotropic drugs

Design outcomes

Primary

Measure	Time frame
1. Nociceptive hemodynamic response to surgical incision recorded as the change in the heart rate, diastolic and systolic blood pressure, measured using a GCE Healthcare model Datex Ohmeda S5 monitor during the surgical procedure 2. Post-surgical pain level, assessed using a visual analogue scale (VAS) at the post-anesthetic care unit arrival, post-anesthetic care unit discharge and during hospitalisation	—

Measure

Time frame

1. Nociceptive hemodynamic response to surgical incision recorded as the change in the heart rate, diastolic and systolic blood pressure, measured using a GCE Healthcare model Datex Ohmeda S5 monitor during the surgical procedure 2. Post-surgical pain level, assessed using a visual analogue scale (VAS) at the post-anesthetic care unit arrival, post-anesthetic care unit discharge and during hospitalisation

—

Secondary

Measure	Time frame
Incidence of adverse effects and side effects, monitored throughout the study and additionally assessed by a post-operative evaluatiob by the surgeon 7-10 days after surgery	—

Countries

Mexico

Contacts

Public ContactHECTOR ZAYAS GONZALEZ

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026