Severe sepsis Infections and Infestations Sepsis
Conditions
Interventions
Patients in the study group (n = 21) received intravenous immunoglobulin preparation (Pentaglobin®) in addition to standard therapy. Pentaglobin® was started on the day of diagnosis of severe sepsis.
Sponsors
Istanbul University (Turkey)
Eligibility
Inclusion criteria
Inclusion criteria: Thirty-nine patients with severe sepsis, defined as: 1. Temperature of greater than 38°C or less than 36°C 2. Heart rate of greater than 90 beats/min 3. Respiratory rate greater than 20/min or arterial carbon dioxide pressure (PaCO2) less than 32 mmHg 4. White blood cell count greater than 12000/mm^3 or less than 4000/mm^3 5. Documented infection and dysfunction of an organ or hypotension
Exclusion criteria
Exclusion criteria: Does not comply with above inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Procalcitonin (PCT) measurements; blood samples were taken daily for eight days following study admission. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Severity of critical illness, assessed by obtaining daily acute physiological and chronic health evaluation score (APACHE II) 2. Sequential organ failure assessment (SOFA) score used to assess the development of organ failure 3. Duration of mechanical ventilation 4. Length of stay in the intensive care unit 5. Septic shock incidence 6. 28-day mortality rate | — |
Countries
Turkey
Outcome results
None listed