Skip to content

The effects of blood flow restriction on fatigue and metabolic stress

The physiological response of low-load resistance exercise with blood flow restriction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN28808565
Enrollment
15
Registered
2024-09-23
Start date
2021-09-01
Completion date
Unknown
Last updated
2024-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impact of blood flow restriction on metabolic stress neuromuscular fatigue Nutritional, Metabolic, Endocrine

Interventions

Using a randomized, cross-over design, participants completed one of two experimental conditions: Low load (30% of 1 repetition maximum) + Blood flow restriction (BFR
or High load (65% of 1 repetition maximum [1RM]) + non-BFR. Participants were randomized using a free online randomization tool. During baseline testing, participants had limb occlusion pressure (50%)
Norsearch, Australia). In both conditions, participants completed 1 set of 30 repetitions in their respective resistance training protocol, at the assigned load, and then 3 sets with a maximum number

Sponsors

University of Wisconsin–La Crosse
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Recreationally active male or female 2. Aged between 18 and 27 years old

Exclusion criteria

Exclusion criteria: 1. Neuromuscular conditions 2. Risk factors for cardiovascular disease 3. Prior history of stroke or blood clots

Design outcomes

Primary

MeasureTime frame
1. Blood lactate measured using a Lactate Scout (Sports Resource Group, USA) handheld analysis device at baseline and following the 4th (final) set of back squat exercises 2. Vertical jump height measured using a 27” x 27” jump mat (Just Jump System, Probotics, AL, USA) at baseline and following the 4th (final) set of back squat exercises

Secondary

MeasureTime frame
1. Ratings of perceived exertion measured using Borg’s 10-point ratings of perceived exertion (0-10) scale at baseline and immediately following each set of the back squat exercise 2. Hemodynamic responses measured using a mercurial sphygmomanometer (American Diagnostic Corporation, model #AD-720) before and after the back squat exercise, in addition to post-inflation of the BFR cuffs for the BFR condition only

Countries

United States of America

Contacts

Public ContactAndrew Jagim
jagim.andrew@mayo.edu+1 7017304842

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026