Idiopathic or mild male infertility Pregnancy and Childbirth
Conditions
Interventions
Standard IVF, or low dose follicle stimulating hormone (FSH) with IVF or IUI
Sponsors
The Royal Women's Hospital (Australia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Infertility of 12 months or longer duration 2. Primary or secondary infertility 3. New patient or patient returning after an interval of longer than 1 year 4. Female age 18-42, male age 18-60 years 5. Detailed male and female partner clinical evaluation, investigation of semen quality and objective evidence of ovulation and tubal patency
Exclusion criteria
Exclusion criteria: 1. Coital disorders, including infrequent or mistimed coitus (50% of motile sperm together with blocked sperm mucus penetration: < 3 cm at 1h in the capillary tube test), reduced sperm zona pellucida (ZP) binding (ratio <0.3) or disordered ZP-induced acrosome reaction (ZPIAR) (<16%) confirmed in 2 sperm ZP interaction tests, or less than 2 million motile sperm for IUI assessed by trial sperm preparation 4. Untreated ovulatory disorders (patients treated for 6 ovulatory cycles without a pregnancy can enter the trial) 5. Ovarian endometrioma (patients with treated or untreated mild endometriosis can enter the trial) 6. Miscellaneous (for example: a contraindication to multiple pregnancy) 7. Currently treated patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Added 16/12/2008: Clinical pregnancy (ultrasound foetal heart[s]). | — |
Secondary
| Measure | Time frame |
|---|---|
| Added 16/12/2008: Economic analysis: relative cost per live birth pregnancy. | — |
Countries
Australia
Outcome results
None listed