Multicentre randomised trial of 'once only' flexible sigmoidoscopy screening for prevention of bowel cancer morbidity and mortality

Conditions

Colorectal cancer Cancer Colorectal

Rhea Harewood, Kate Wooldrage, Emma C Robbins, James Kinross, Christian von Wagner et al. (6 authors)

BMJ Open Gastroenterology2025-06-01

10.1136/bmjgast-2025-001787

The impact of patient-reported factors of endoscopic screening experience on attendance at future examinations and distal colorectal cancer incidence

Sharon Power, Kate Wooldrage, Siwan Thomas‐Gibson, Amanda J. Cross

BMC Cancer2025-03-06

10.1186/s12885-025-13771-3

Higher Adenoma Detection Rates at Screening Associated With Lower Long-Term Colorectal Cancer Incidence and Mortality.

Cross AJ, Robbins EC, Saunders BP, Duffy SW, Wooldrage K.

2020-09-1228 citations

10.1016/j.cgh.2020.09.020

Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial.

Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, Parkin DM, Wardle J, Duffy SW, Cuzick J, UK Flexible Sigmoidoscopy Trial Investigators.

2010-04-271,091 citations

10.1016/s0140-6736(10)60551-x

Interventions

'Once only' flexible sigmoidoscopy screening/control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All 55-64 year old men and women from selected general practices

Exclusion criteria

Exclusion criteria: 1. If incapable of providing informed consent 2. Patients with a personal or family history of bowel cancer (greater than two family members) 3. A recent sigmoidoscopy or colonoscopy 4. Severe illness or life expectancy of less than 5 years

Design outcomes

Primary

Measure	Time frame
Incidence, mortality from colorectal cancer	—

Secondary

Measure	Time frame
Psychological morbidity, costs to the NHS	—

Countries

England, United Kingdom

Outcome results

None listed