Topic: Respiratory
Conditions
Interventions
Dietary and house dust mite allergy prevention.
Sputum Induction:
This involves breathing in a mist of saline solution, which helps make phlegm in the lungs, which is then collected in a sputum pot.
Sponsors
Isle of Wight Healthcare NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Everyone (120 subjects) who participated in the original Isle of Wight Primary Prevention study will be asked if they wish to participate.
Exclusion criteria
Exclusion criteria: 1. Any patient who does not wish to participate 2. Any patient where their lung function test suggests that they would be at risk of significant bronchospasm and/or clinical suspicion is high that they would not tolerate sputum induction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of sputum eosinophils in the intervention versus control group. Sputum samples will be collected during a visit to the research centre, with preparation and analysis taking place after. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of other cells (1) neutrophils, (2): epithelial cells in sputum in the two groups 2. Eosinophilic inflammatory markers (eosinophilic cationic protein and interleukin 5) in sputum supernatant in the two groups Sputum samples will be collected during a visit to the research centre, with preparation and analysis taking place after. | — |
Countries
United Kingdom
Outcome results
None listed