Can music at a frequency of 432 Hz reduce dental anxiety in patients undergoing tooth extraction?

Effect of music at 432 Hz in dental anxiety and salivary cortisol levels in patients undergoing tooth extraction. A randomized clinical trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN28195632

Enrollment

Registered

2019-01-23

Start date

2019-01-01

Completion date

Unknown

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental anxiety Mental and Behavioural Disorders Specific (isolated) phobias

Interventions

The study will consist of three arms, the participants of the three groups will be randomized by a simple randomization using an online randomizer. All the participants will be intervened once, when t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. A Modified Dental Anxiety Scale in Spanish (MDAS) score greater > 9 points 2. 15 to 30 years of age 3. ASA I 4. Requiring simple tooth extraction.

Exclusion criteria

Exclusion criteria: 1. Suffering from systemic diseases 1.1. Diabetes 1.2. Immunosuppression 1.3. Hypertension 1.4. Thyroid pathology 1.5. Heart disease 1.6. Alcoholism 1.7. Pheochromocytoma 1.8. Cushing's syndrome 2. Heavy smokers (consumption of > 10 cigarettes a day) 3. Receiving permanent pharmacological treatment 3.1. Tricyclic antidepressants, 3.2. Anticholinergics 3.3. Benzodiazepines 3.4. Antihypertensives 3.5. Diuretics 3.6. Phenothiazines 3.7. Narcotics 3.8. Synthetic glucocorticoids (prednisone and prednisolone) 3.9. Phenytoin 4. Pregnant women 5. Pericoronitis or infection at the time of surgery or 10 days before surgery.

Design outcomes

Primary

Measure	Time frame
1. Dental anxiety will be measured using the CORAH- MDAS questionnaire before and after music stimulation. 2. Salivary Cortisol will be measured using 3 ml of unstimulated saliva before and after music stimulation. 2.1. Saliva samples will be transported under refrigeration conditions and then frozen at -20 ºC until laboratory analysis. 2.2. For statistical analysis, the amount of saliva secreted will be expressed in mL / min and cortisol expressed in ug / dl.	—

Measure

Time frame

1. Dental anxiety will be measured using the CORAH- MDAS questionnaire before and after music stimulation. 2. Salivary Cortisol will be measured using 3 ml of unstimulated saliva before and after music stimulation. 2.1. Saliva samples will be transported under refrigeration conditions and then frozen at -20 ºC until laboratory analysis. 2.2. For statistical analysis, the amount of saliva secreted will be expressed in mL / min and cortisol expressed in ug / dl.

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Countries

Chile

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026