The effects of angiotensin 2 blockade and long acting nitrates on arterial stiffness in patients with Marfan Syndrome. A placebo controlled study (NITRATES)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN28168217

Enrollment

Registered

2004-09-30

Start date

2003-06-23

Completion date

Unknown

Last updated

2018-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Marfan syndrome Not Applicable Other specified congenital malformation syndromes affecting multiple systems

Interventions

Patients with Marfan Syndrome (MFS) develop dissection of the aorta and aortic valve incompetence which can lead to premature death. Administration of beta adrenoceptor blockers slows aortic dissectio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 30 subjects aged 18-30

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

Measure	Time frame
Not provided at time of registration	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026