Recurrent miscarriage Pregnancy and Childbirth Spontaneous abortion
Conditions
Interventions
Group one: these women will be allocated oral prednisolone, 20 mg a day for six weeks, then 10 mg for one week, then 5 mg for one week.
Group two: these women will be allocated oral placebo tablets wi
Sponsors
Liverpool Women's NHS Foundation Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women with three or more consecutive idiopathic first trimester miscarriages and more than 5% of endometrial cells CD56+ 2. Women aged between 20 and 40 years
Exclusion criteria
Exclusion criteria: 1. Known cause for pregnancy losses 2. Anti-phospholipid antibody syndrome 3. Parental balanced translocation, uterine anomaly 4. Known thrombophilia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate, this outcome will be measured in accordance with each woman's achieved gestation period. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Conception rate 2. First trimester losses 3. Second trimester miscarriages 4. Still births 5. Intrauterine growth restriction 6. Pre-eclampsia 7. Abruption 8. Gestation at delivery 9. Foetal abnormality 10. Side effects of steroids Secondary outcomes will be measured during routine high risk antenatal clinic appointments (every 2 weeks up until 12 weeks gestation; 28 weeks and 34 weeks gestation). The women will be in regular contact with the Chief Investigator as and when they feel the need (if they have concerns) and during their routine clinic appointments - during which secondary outcomes will be reported. | — |
Countries
United Kingdom
Outcome results
None listed