Correction of acidosis in hemodialysis patients. Effects on protein metabolism, investigated by tracer technique and messenger-ribonucleic acid determination for ubuquitin and proteasome subunits.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN27844532

Enrollment

Registered

2006-07-03

Start date

1997-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End-stage renal failure Nutritional, Metabolic, Endocrine Renal failure

Interventions

Adjustments of acid-base balance - in each patient, protein turnover will be measured twice, at a standard bicarbonate concentration of 25 mmol/l respectively, with an interval between the two measure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Clinically stable hemodialysis patients 2. >18 Years of age

Exclusion criteria

Exclusion criteria: 1. Clinically obvious malnutrition 2. Ongoing infection 3. Diabetes mellitus 4. Untreated congestive heart failure 5. Treatment with corticosteroids or other immunosuppressive agents

Design outcomes

Primary

Measure	Time frame
Muscle protein turnover	—

Secondary

Measure	Time frame
1. messenger-Ribonucleic Acid (mRNA) for ubuquitin and proteasome subunits 2. Plasma and muscle intracellular amino acid concentrations 3. Serum albumin	—

Countries

Sweden

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026